Peer-reviewed veterinary case report
Weimaraner puppies with fever and bone disease after vaccination
By Abeles, V et al.·Published in The Veterinary record·1999·Department of Clinical Sciences·View original on PubMed →
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Original publication title: Hypertrophic osteodystrophy in six weimaraner puppies associated with systemic signs.
- Species:
- dog
Plain-English summary
Six Weimaraner puppies developed fever and other serious symptoms like gastrointestinal and respiratory issues after being vaccinated. Within ten days of vaccination, they showed signs of hypertrophic osteodystrophy, a condition that affects their bones. The puppies had abnormal blood test results and X-rays showed problems in both their front and back legs. While rest and pain relief medications didn't help much, treatment with corticosteroids led to the best improvement in their condition.
People also search for: Weimaraner puppy fever after vaccination · hypertrophic osteodystrophy treatment · puppy gastrointestinal problems · corticosteroids for puppy bone issues
Abstract
Six weimaraner puppies, five of which were genetically related, showed systemic signs associated with hypertrophic osteodystrophy, including fever and involvement of the gastrointestinal, respiratory or nervous systems, in addition to the metaphyseal lesions. In five of the dogs the clinical signs developed less than 10 days after they had been vaccinated with a modified live virus vaccine. Radiographic findings suggested that both the hindlimbs and forelimbs were equally involved in the disease process. Abnormal haematological findings included leucocytosis with neutrophilia and monocytosis, and there was a consistent increase in the activity of alkaline phosphatase. Serum protein electrophoretic studies of three of the dogs revealed hypogammaglobulinaemia and abetaglobulinaemia in two of them. Conservative treatment with rest and non-steroidal anti-inflammatory drugs had little effect, and treatment with corticosteroids appeared to give the best results.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/10466830/