Peer-reviewed veterinary case report
No link found between MHC DQA1 alleles and bone disease in Weimaraners
By Crumlish, Patrick T et al.·Published in Veterinary journal (London, England : 1997)·2006·Department of Small Animal Clinical Studies·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Hypertrophic osteodystrophy in the Weimaraner dog: lack of association between DQA1 alleles of the canine MHC and hypertrophic osteodystrophy.
- Species:
- dog
Plain-English summary
A group of Weimaraner dogs developed a bone disease called hypertrophic osteodystrophy (HOD) after recent vaccinations, showing symptoms within six weeks. Researchers looked for a link between specific genetic markers and the disease but found no direct association. This suggests that while vaccination may trigger HOD, it isn't caused by a specific vaccine or genetic factor. Pet owners should be aware of this potential risk and discuss any concerns with their veterinarian, especially if their dog shows signs of HOD after vaccination.
People also search for: Weimaraner bone disease symptoms · dog vaccination side effects · hypertrophic osteodystrophy treatment
Abstract
Hypertrophic osteodystrophy (HOD) is a canine bone disease that affects mainly large breed dogs, including the Weimaraner, and studies have shown a link between recent vaccination with a modified live virus and the onset of HOD in this breed. In humans, it has been suggested that human leukocyte antigen (HLA) alleles can influence antibody response to vaccination. The aim of this study was to investigate whether there is an association between the development of HOD in Weimaraners and MHC alleles at the DLA-DQA1 locus in a group of 33 unrelated dogs. The DQA1 allele and genotype frequencies were determined by sequence-based typing. Although clinical signs developed within six weeks of vaccination in all 12 dogs for which information was available, no association was found between DQA1 alleles and HOD in this population of Weimaraner dogs. A role for other immune-response genes in the pathogenesis of HOD should not however be ruled out. Whereas recent vaccination may be a trigger for the disease, it was concluded that there is no specific vaccine that is most responsible for the expression of the disease.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16490714/