Peer-reviewed veterinary case report
Scottish Terrier with brain inflammation causing hormone loss
By Polledo, L et al.Ā·Published in Journal of veterinary internal medicineĀ·2017Ā·Pathology Department, United KingdomĀ·View original on PubMed ā
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Original publication title: Hypophysitis, Panhypopituitarism, and Hypothalamitis in a Scottish Terrier Dog.
- Species:
- dog
Plain-English summary
A 6-year-old male neutered Scottish Terrier was brought in after showing signs of extreme tiredness and not wanting to eat for a week. The vet found a problem in the dog's brain and discovered that he had a condition called panhypopituitarism, which means his pituitary gland wasn't working properly. An MRI showed a mass in the brain that suggested a possible tumor. Unfortunately, the dog's condition worsened quickly, and further tests couldn't be done. A tissue sample later revealed inflammation of the pituitary gland, likely due to an autoimmune issue.
People also search for: dog lethargy and not eating Ā· Scottish Terrier brain tumor symptoms Ā· autoimmune disease in dogs
Abstract
A 6-year old male neutered Scottish Terrier was referred with a 1 week history of progressive lethargy and anorexia. Neurological examination localized a lesion to the forebrain and hormonal testing showed panhypopituitarism. Magnetic resonance imaging (MRI) of the brain revealed a rounded, well-defined, suprasellar central mass. The mass was slightly hyperintense to the cortical grey matter on T2-weighted (T2W), hypointense on T1-weighted (T1W) images and without T2* signal void. There was a central fusiform enhancement of the mass after contrast administration which raised the suspicion of a pituitary neoplasm. Rapid deterioration of the dog prevented further clinical investigations. Histopathologic examination revealed a lymphocytic panhypophysitis of unknown origin suspected autoimmune involving the hypothalamus (hypothalamitis). This is a unique case report of a dog presenting with inflammatory hypophysitis and hypothalamitis of suspected autoimmune origin with detailed clinical, MRI, histology and immunohistochemistry findings.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28745808/