Peer-reviewed veterinary case report
Hypotensive effect of Chamaemelum nobile aqueous extract in spontaneously hypertensive rats.
- Journal:
- Clinical and experimental hypertension (New York, N.Y. : 1993)
- Year:
- 2009
- Authors:
- Zeggwagh, Naoufel Ali et al.
- Affiliation:
- UFRPNPE B. P.
- Species:
- rodent
Abstract
This study aims to evaluate the hypotensive effect of Chamaemelum nobile aqueous extract (CNAE) in spontaneously hypertensive rats (SHRs). Single oral administration of CNAE (140 mg/kg) produced a significant reduction (p < 0.05) in systolic blood pressure (SBP) after 24 h of the administration. Daily oral administration of CNAE (140 mg/kg) during 3 weeks produced a significant reduction in SBP in the day 8 (p < 0.01) of treatment. Furthermore, CNAE produced a significant increase in urinary output and electrolytes excretion (p < 0.01) from the day 8 to the end of treatment. We conclude that CNAE possesses a hypotensive and diuretic effect in SHR.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19811353/