Peer-reviewed veterinary case report
Identification and Analysis of Type 2 Innate Lymphoid Cells in Rhinovirus-Infected Mouse Model of Asthma.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2025
- Authors:
- Rajput, Charu
- Affiliation:
- Lewis Katz Medical School · United States
- Species:
- rodent
Abstract
Early-life respiratory tract infections by rhinovirus (RV) are considered risk factors for asthma development. Previous studies have shown that RV infection of six-day-old BALB/c mice, but not mature mice, induces an asthma-like phenotype, including mucous metaplasia and airway hyperresponsiveness, which is associated with the expansion of type 2 innate lymphoid cells (ILC2s). This chapter describes the isolation and analysis of ILC2s from RV-infected neonatal mouse lungs by flow cytometry, in vitro culture and adoptive transfer.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/40016464/