Peer-reviewed veterinary case report
Bacteria causing severe corneal ulcers in dogs in Thailand and their
By Ekapopphan, Daneeya et al.·Published in The Journal of veterinary medical science·2018·Department of Pre-clinic and Applied Animal Science·View original on PubMed →
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Original publication title: Identification and antimicrobial susceptibility of microorganisms isolated from severe corneal ulcers of dogs in Thailand.
- Species:
- dog
Plain-English summary
A group of dogs with severe corneal ulcers were examined to find out what bacteria were causing their infections and how resistant these bacteria were to common antibiotics. Out of 32 dogs, 26 had bacteria growing in their samples, with Staphylococcus being the most common. Many of these Staphylococcus bacteria were resistant to several antibiotics, making treatment challenging. However, chloramphenicol was found to be effective against most of the resistant strains. This highlights the importance of careful antibiotic selection for treating severe eye infections in dogs.
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Abstract
This study aims to determine the microbiological profile and risk factors associated with antimicrobial-resistant bacteria in canine severe corneal ulcers. Thirty-two corneal and conjunctival swabs were collected from dogs with diagnosed severe corneal ulcers that presented to Prasu-Arthorn veterinary teaching hospital in Nakhon Pathom, Thailand from June 2015 to June 2016. Microorganisms were identified by means of genotypic and phenotypic approaches. Of 32 ulcers sampled, 26 (81.3%) yielded culturable microorganisms with 24 bacterial isolates and 7 fungal isolates. The most commonly isolated bacteria were Staphylococcus spp. (45.8%, 11/24) and Pseudomonas aeruginosa (20.8%, 5/24). Out of 11 staphylococcal isolates identified, 10 carried the mecA gene providing methicillin resistance. The extended-spectrum β-lactamase (ESBL) encoding genes blaand blawere found in an Acinetobacter lwoffii isolate, and blawas found in a P. aeruginosa isolate. Based on the Clinical Laboratory Standards Institute (CLSI) and European Committee on Antimicrobial Susceptibility Testing (EUCAST) breakpoint criteria, minimum inhibitory concentrations values showed that all bacteria, except for staphylococci, were susceptible to current ophthalmic antibiotics. More than 50% of staphylococci were resistant to all generations of fluoroquinolones and fusidic acid. Chloramphenicol was highly active against staphylococci (81.3% susceptible). The width (P=0.02) and the depth (P=0.04) of ulcers predicted greater risk of yielding resistant bacteria. The identification of antimicrobial-resistant bacteria prompts practitioners to be prudent when choosing ophthalmic antibiotics for severe corneal ulcers.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29925698/