Peer-reviewed veterinary case report
Avian-origin H3N2 flu found in dogs in Liaoning China 2012
By Yang, Xinyan et al.·Published in Virus genes·2014·Haikou Center for Disease Control & Prevention, China·View original on PubMed →
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Original publication title: Identification and genetic characterization of avian-origin H3N2 canine influenza viruses isolated from the Liaoning province of China in 2012.
- Species:
- dog
Plain-English summary
A group of dogs in China showed signs of respiratory problems, and testing revealed that some were infected with the H3N2 canine influenza virus. Out of 158 blood samples, 10.8% tested positive for this virus, which is linked to strains found in birds. Two specific strains were isolated from the dogs, showing a high genetic similarity to other H3N2 viruses circulating in Asia. The findings suggest that this type of canine influenza is now common in the region, highlighting the need for better monitoring and vaccine development to protect dogs from this illness.
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Abstract
A total of 158 serum samples and 510 nasal swab specimens were collected between September 2010 and May 2012, from dogs exhibiting respiratory symptoms, in order to investigate the epidemiology of H3N2 canine influenza viruses (CIVs) in the Liaoning province of China. Serological surveillance demonstrated that 10.8 % (17/158) of serum samples were positive for H3N2 canine influenza. Two H3N2 influenza viruses, A/canine/Liaoning/27/2012 and A/canine/Liaoning/H6/2012, were isolated from pet dogs in 2012. Phylogenetic analysis indicated that the genes from these two viruses were closely related to those of avian-origin, H3N2 subtype CIVs from China and Thailand. Genetic analysis of eight genes revealed that these two H3N2 canine influenza isolates were highly similar (99.2-99.8 %) to the current common strains in Asia. Analysis of the genotype demonstrated that each gene of the two strains in this study had the same genotype (K, G, E, 3B, F, 2D, F, 1E) as those prevalent in H3N2 CIVs. Our findings further confirm that avian-origin H3N2 canine influenza has become established in China. Conducting extensive serological and epidemiological surveillance is necessary to develop an effective vaccine against this disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24928168/