Peer-reviewed veterinary case report
Genes linked to delayed bleeding after surgery in Scottish deerhounds
By Court, Michael H et al.·Published in Journal of veterinary internal medicine·2023·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Identification by whole genome sequencing of genes associated with delayed postoperative hemorrhage in Scottish deerhounds.
- Species:
- dog
Plain-English summary
A group of Scottish deerhounds was studied to understand why some dogs experience delayed postoperative hemorrhage (DEPOH) after surgery. Researchers found that a specific gene variant (SERPINF2) is linked to a higher risk of this condition. Dogs with certain genetic makeups were significantly more likely to experience DEPOH compared to those without the variant. This discovery suggests that genetic testing could help identify deerhounds at risk for this serious complication, allowing for better pre-surgical planning and care.
People also search for: Scottish deerhound surgery complications · delayed bleeding after dog surgery · genetic testing for dog health risks
Abstract
BACKGROUND: Delayed postoperative hemorrhage (DEPOH) is an important health concern for Scottish deerhounds. HYPOTHESIS/OBJECTIVES: Identify genes associated with DEPOH in Scottish deerhounds. ANIMALS: Two hundred sixty-nine privately owned Scottish deerhounds. METHODS: Retrospective case-control study. DEPOH cases and controls were identified through an owner health survey. Genome-wide association analysis was performed using whole genome sequences from 8 cases and 17 controls. All cases and controls were genotyped for selected variants. RESULTS: Of 269 dogs, 10 met inclusion and exclusion criteria for DEPOH, while 62 controls had undergone similar surgical procedures without DEPOH. Genome-wide association analysis identified a single locus on chromosome 9 spanning 40 genes. One of these genes (SERPINF2 encoding alpha-2 antiplasmin) was directly linked to the pathophysiology of DEPOH. The entire cohort was genotyped for a missense SERPINF2 variant (c.605 C>T; p.A202V). Compared to dogs with the reference C/C genotype, the likelihood of DEPOH was significantly higher for dogs with the T/T genotype (odds ratio [OR] = 1235; 95% confidence interval [CI] = 23-6752; P = 0.0005) and with the C/T genotype (OR = 28; 95% CI = 1.4-542; P = 0.03). CONCLUSIONS AND CLINICAL IMPORTANCE: SERPINF2 is associated with DEPOH in Scottish deerhounds. Genetic testing might be able to identify dogs that are susceptible to DEPOH.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36780177/