Peer-reviewed veterinary case report
Identification of a cold agglutinin with anti-Pr3 specificity.
- Journal:
- Scandinavian journal of haematology
- Year:
- 1982
- Authors:
- Birgens, H S et al.
Plain-English summary
In a study, researchers found a specific type of antibody called a cold agglutinin in the blood of a 38-year-old woman. This antibody was identified as having a particular focus on a part of the immune system known as Pr3. Further tests showed that this cold agglutinin reacted strongly with certain treated red blood cells, indicating that it specifically targets human red blood cells. This discovery suggests that there may be different types of antibodies that target Pr3, which was not fully understood before. The findings highlight the complexity of the immune response and the need for more research in this area.
Abstract
An apparent monoclonal IgM, kappa-cold agglutinin with anti-Pr specificity was detected in the serum of a 38-year old woman. Haemagglutination inhibition studies disclosed the subspecificity anti-Pr3, since the cold agglutinin was strongly inhibited by carbodiimide-treated erythrocyte glycoproteins. Studies with animal cells showed that the corresponding Pr3 determinant was found only on human red cells. This is in contrast to earlier findings and indicates that distinct fine specificities within anti-Pr3 antibodies might well exist.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/6183733/