Peer-reviewed veterinary case report
New genetic type of distemper virus found in vaccinated Mexican dogs
By Simon-Martínez, J et al.·Published in Veterinary journal (London, England : 1997)·2008·Centro de Investigació·View original on PubMed →
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Original publication title: Identification of a genetic variant of canine distemper virus from clinical cases in two vaccinated dogs in Mexico.
- Species:
- dog
Plain-English summary
Two vaccinated dogs in Mexico were diagnosed with canine distemper virus (CDV), a serious and contagious illness. Despite being vaccinated, these dogs showed symptoms of the disease, and tests confirmed the presence of a new genetic variant of the virus that is different from the strains used in vaccines. This finding indicates that a new lineage of CDV may be circulating in the area, which could explain the increasing cases of distemper in vaccinated dogs. It's important for pet owners to be aware of this potential risk and discuss vaccination and prevention strategies with their veterinarian.
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Abstract
Canine distemper virus (CDV) is a highly contagious viral pathogen of worldwide distribution that can cause lethal disease in dogs and other mammals. Genetic diversity is found among reference strains and isolates of CDV, mainly in the haemagglutinin protein (H), fusion protein (F) and nucleoprotein (N), and this may be associated with the increasing incidence of distemper in dogs. CDV was identified by RT-PCR in serum samples taken from two clinically diseased, previously vaccinated Mexican dogs. Subsequently, in both samples, a fragment of the CDV N gene was sequenced revealing a 100% identity between nucleotide sequences. However, the sequence obtained was different to that found in virus strains used in vaccines and in isolates reported elsewhere, but was closely related to A75/17, 1127/Gi95, and 2495/Gi95 sequences from USA and Germany, and clustered with 1127/Gi95 and 2495/Gi95 strains. The results suggest that a novel CDV lineage may be present in Mexico.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17382567/