Peer-reviewed veterinary case report
Nonsense mutation in cat ABCB1 gene linked to drug reactions
By Mealey, K L & Burke, N S·Published in Journal of veterinary pharmacology and therapeutics·2015·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Identification of a nonsense mutation in feline ABCB1.
- Species:
- cat
Plain-English summary
A cat that experienced severe side effects after receiving ivermectin was found to have a specific genetic mutation (ABCB11930_1931del TC) that affects how certain drugs are processed in the body. This mutation was identified in one of the cats that showed signs of central nervous system toxicity, while other cats in the study did not have this mutation and did not experience similar reactions. The findings suggest that this genetic change could make some cats more sensitive to certain medications, similar to a known mutation in dogs. Understanding this can help veterinarians choose safer treatments for affected cats.
People also search for: cat ivermectin side effects · cat genetic mutation medication · why is my cat acting strange after medication
Abstract
The aim of this study was to sequence all exons of the ABCB1 (MDR1) gene in cats that had experienced adverse reactions to P-glycoprotein substrate drugs (phenotyped cats). Eight phenotyped cats were included in the study consisting of eight cats that experienced central nervous system toxicosis after receiving ivermectin (n = 2), a combination product containing moxidectin and imidacloprid (n = 3), a combination product containing praziquantel and emodepside (n = 1) or selamectin (n = 2), and 1 cat that received the product containing praziquantel and emodepside but did not experience toxicity (n = 1). Fifteen exons contained polymorphisms and twelve exons showed no variation from the reference sequence. The most significant finding was a nonsense mutation (ABCB11930_1931del TC) in one of the ivermectin-treated cats. This cat was homozygous for the deletion mutation. All of the other phenotyped cats were homozygous for the wild-type allele. However, 14 missense mutations were identified in one or more phenotyped cats. ABCB11930_1931del TC was also identified in four nonphenotyped cats (one homozygous and three heterozygous for the mutant allele). Cats affected by ABCB11930_1931del TC would be expected to have a similar phenotype as dogs with the previously characterized ABCB1-1Δ mutation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25660379/