Peer-reviewed veterinary case report
Platelet function defect causing bleeding in Spitz dogs
By Boudreaux, M K et al.·Published in Journal of veterinary internal medicine·1994·Department of Pathobiology·View original on PubMed →
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Original publication title: Identification of an intrinsic platelet function defect in Spitz dogs.
- Species:
- dog
Plain-English summary
Two Spitz dogs were found to have a problem with their platelets, which are important for blood clotting. These dogs experienced chronic bleeding from their nose, mouth, and gastrointestinal tract. Tests showed that their platelets did not respond properly to certain triggers that normally help them clump together to stop bleeding. Despite this issue, their platelets looked normal under a microscope. The condition seems similar to a known platelet defect in Basset hounds.
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Abstract
A recently identified intrinsic platelet function defect in 2 Spitz dogs is described. Both affected dogs had a history of chronic intermittent bleeding primarily from the nasal, oral, and gastrointestinal mucosa. Platelet aggregation in response to adenosine diphosphate (ADP), collagen, and platelet activating factor (PAF) was absent; however, platelet shape change did occur. Platelets aggregated in response to gamma thrombin, although a delayed onset and a reduced velocity of aggregation were present. Platelet 14C-serotonin release was diminished in response to collagen and PAF. Glycoprotein IIIa was detected on the surface of platelets by flow cytometry. Platelets were morphologically normal under light and electron microscopy. Two male Spitz dogs, related to one of the affected dogs, did not have a bleeding diathesis. Collagen-induced platelet aggregation, however, was diminished in these 2 dogs. This platelet defect most closely resembles the defect described in Basset hounds.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/8046682/