Peer-reviewed veterinary case report
Fusidic acid resistance in Staphylococcus pseudintermedius from dogs
By Lim, Yun-Ji et al.·Published in Veterinary dermatology·2020·Laboratory of Veterinary Dermatology and the Research Institute for Veterinary Science, South Korea·View original on PubMed →
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Original publication title: Identification of fusidic acid resistance in clinical isolates of Staphylococcus pseudintermedius from dogs in Korea.
- Species:
- dog
Plain-English summary
A group of dogs with skin infections (pyoderma) and ear infections (otitis) were found to have a type of bacteria called Staphylococcus pseudintermedius that is resistant to a common antibiotic called fusidic acid. Out of 52 samples tested, 14 showed resistance, which can limit treatment options for these infections. The study identified specific genetic changes in the bacteria that contribute to this resistance. It's important for veterinarians to be aware of this resistance to ensure effective treatment for dogs suffering from these infections.
People also search for: dog skin infection treatment · fusidic acid resistance in dogs · Staphylococcus pseudintermedius in dogs
Abstract
BACKGROUND: Staphylococcus pseudintermedius is a major bacterial species associated with canine pyoderma and otitis. Fusidic acid is used to treat skin infections caused by Gram-positive bacteria. The incidence of resistance to fusidic acid in S. pseudintermedius has importance in terms of limiting treatment options for bacterial infections. HYPOTHESIS/OBJECTIVES: To evaluate the occurrence and mechanisms of fusidic acid resistance in clinical isolates of S. pseudintermedius. ANIMALS: Fifty-two S. pseudintermedius isolates were collected from dogs with pyoderma (n = 36) or otitis (n = 16). METHODS AND MATERIALS: The disk diffusion method determined that isolates <24 mm were resistant to fusidic acid. Minimum inhibitory concentrations (MICs) were measured by the E-test in those with confirmed resistance to fusidic acid by the disk diffusion method. Phenotypically fusidic acid resistant isolates were subjected to PCR to detect the presence of resistance-related genes (fusA, fusB, fusC and fusD) and fusA was further sequenced to identify point mutations. RESULTS: Fourteen of 52 (27%) S. pseudintermedius isolates were resistant to fusidic acid and all of these showed low-level resistance. Among fusidic acid resistant isolates, fusA point mutations were confirmed in 11 isolates and amino acid substitutions were found in five. fusC was detected in seven isolates, but neither fusB nor fusD was detected. CONCLUSIONS AND CLINICAL IMPORTANCE: This study demonstrates the occurrence and resistance mechanisms to fusidic acid in clinical isolates of S. pseudintermedius. Continuous monitoring for fusidic acid resistance is recommended.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32115810/