Peer-reviewed veterinary case report
Genetic factors linked to stomach twisting in dogs
By Piras, Ignazio S et al.·Published in Genes·2020·Translational Genomics Research Institute, United States·View original on PubMed →
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Original publication title: Identification of Genetic Susceptibility Factors Associated with Canine Gastric Dilatation-Volvulus.
- Species:
- dog
Plain-English summary
A study found that certain large dog breeds, like Collies, German Shorthaired Pointers, and Great Danes, may have genetic factors that influence their risk of developing gastric dilatation-volvulus (GDV), a serious condition where the stomach twists and can be life-threatening. Researchers identified specific genetic markers that could either increase or decrease the likelihood of GDV in these breeds. This information could help veterinarians understand which dogs are at higher risk and guide preventive measures.
People also search for: dog GDV risk factors · Great Dane stomach problems · Collie genetic health issues
Abstract
Canine gastric dilatation-volvulus (GDV) is a common life-threatening condition occurring primarily in large and giant breeds with a 3.9% to 36.7% lifetime risk. The genetic correlates of GDV have not previously been systematically explored. We undertook an inter-breed genome-wide association analysis (GWAS) of 253 dogs from ten breeds including 106 healthy dogs and 147 dogs with at least one GDV episode. SNP array genotyping followed by imputation was conducted on 241 samples to identify GDV-associated single-nucleotide polymorphisms (SNPs) and copy number variations (CNVs). A subset of 33 dogs (15 healthy dogs and 18 GDV patients from the three most represented breeds) was characterized by whole genome sequencing (WGS). After genome-wide Bonferroni correction, we identified a significant putatively protective intergenic SNP (rs851737064) across all breeds. The signal was most significant in Collies, German Shorthaired Pointers, and Great Danes. Subsequent focused analysis across these three breeds identified 12 significant additional putatively protective or deleterious SNPs. Notable significant SNPs included those occurring in genes involved in gastric tone and motility includingand. These data provide important new clues to canine GDV risk factors and facilitate generation of hypotheses regarding the genetic and molecular underpinnings this syndrome.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33167491/