Peer-reviewed veterinary case report
Identification of herpes simplex virus type 1 proteins encoded within the first 1.5 kb of the latency-associated transcript.
- Journal:
- Journal of neurovirology
- Year:
- 2009
- Authors:
- Henderson, Gail et al.
- Affiliation:
- Department of Veterinary and Biomedical Sciences · United States
- Species:
- rodent
Abstract
Expression of the first 1.5 kb of the latency-associated transcript (LAT) that is encoded by herpes simplex virus type 1 (HSV-1) is sufficient for wild-type (wt) levels of reactivation from latency in small animal models. Peptide-specific immunoglobulin G (IgG) was generated against open reading frames (ORFs) that are located within the first 1.5 kb of LAT coding sequences. Cells stably transfected with LAT or trigeminal ganglionic neurons of mice infected with a LAT expressing virus appeared to express the L2 or L8 ORF. Only L2 ORF expression was readily detected in trigeminal ganglionic neurons of latently infected mice.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20175695/