Peer-reviewed veterinary case report
Predicting inflammatory response to C. Novyi-NT therapy in dogs
By DeClue, Amy E et al.·Published in BMC veterinary research·2018·Department of Veterinary Medicine and Surgery, United States·View original on PubMed →
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Original publication title: Identification of immunologic and clinical characteristics that predict inflammatory response to C. Novyi-NT bacteriolytic immunotherapy.
- Species:
- dog
Plain-English summary
A group of dogs with tumors were treated with a new therapy called Clostridium novyi-NT (CNV-NT) to see how their immune systems reacted. Researchers found that dogs who had a higher heart rate, larger tumors, and certain immune cell activity were more likely to develop an inflammatory response to the treatment. This inflammation could be a sign that the therapy is working. Understanding these factors can help veterinarians predict which dogs might benefit most from this innovative cancer treatment.
People also search for: dog cancer treatment · Clostridium novyi-NT for dogs · dog tumor immune response
Abstract
BACKGROUND: Clostridium novyi-NT (CNV-NT), has shown promise as a bacterolytic therapy for solid tumors in mouse models and in dogs with naturally developing neoplasia. Factors that impact the immunologic response to therapy are largely unknown. The goal of this pilot study was to determine if plasma immune biomarkers, immune cell function, peripheral blood cytological composition and tumor characteristics including evaluation of a PET imaging surrogate of tumor tissue hypoxia could predict which dogs with naturally developing naïve neoplasia would develop an inflammatory response to CNV-NT. RESULTS: Dogs that developed an inflammatory response to CNV-NT had a higher heart rate, larger gross tumor volume, greater tumor [Cu]ATSM SUV, increased constitutive leukocyte IL-10 production, more robust NK cell-like function and greater peripheral blood lymphocyte counts compared to dogs that did not develop an inflammatory response to CNV-NT. Of these, unstimulated leukocyte IL-10 production, heart rate, and gross tumor volume appeared to be the best predictors of which dogs will develop an inflammatory response to CNV-NT. CONCLUSIONS: Development of inflammation in response to CNV-NT is best predicted by pretreatment unstimulated leukocyte IL-10 production, heart rate, and gross tumor volume.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29606140/