Peer-reviewed veterinary case report
Major allergens from Malassezia yeast in dogs with itchy skin
By Chen, Tai-An et al.·Published in Veterinary dermatology·2002·Department of Veterinary Clinical Studies, United Kingdom·View original on PubMed →
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Original publication title: Identification of major allergens of Malassezia pachydermatis in dogs with atopic dermatitis and Malassezia overgrowth.
- Species:
- dog
Plain-English summary
A group of 28 dogs with atopic dermatitis (a skin allergy) and Malassezia overgrowth (a type of yeast infection) were found to have a stronger immune response to certain proteins from the Malassezia pachydermatis yeast compared to 22 healthy dogs. The study identified four specific proteins that triggered a significant allergic reaction in more than half of the affected dogs. This suggests that these proteins may play a key role in the skin problems seen in atopic dogs. Understanding these allergens could help veterinarians develop better treatments for dogs suffering from these conditions.
People also search for: dog skin allergies treatment · Malassezia dermatitis in dogs · atopic dermatitis dog symptoms
Abstract
We have previously shown that both atopic and normal dogs generate an IgG response to antigens of Malassezia pachydermatis. The aim of this study was to compare IgE responses to separated proteins of M. pachydermatis in 28 atopic dogs with Malassezia dermatitis and 22 clinically normal dogs using Western immunoblotting. Six different detection systems were evaluated in order to assess sensitivity and eliminate nonspecific binding and cross-reactivity. The protocol yielding the best results utilized a monoclonal mouse antidog IgE, an alkaline phosphatase conjugated goat antimouse IgG which had been passed through a canine IgG column 3 times, a chemiluminescent substrate and a digital imaging system. Proteins of 45, 52, 56 and 63 kDa were recognized by more than 50% of the atopic dog sera and thus represented major allergens. Only a minority of normal dogs showed faint IgE binding to these proteins. The results indicate that the majority of atopic dogs with Malassezia dermatitis have a greater IgE response than normal dogs, suggesting an IgE-mediated immune response may be clinically important in the pathogenesis of the disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/12074703/