Peer-reviewed veterinary case report
Genetic markers linked to progressive retinal atrophy in American
By Moody, Jessica A et al.·Published in American journal of veterinary research·2005·Department of Pathobiology, United States·View original on PubMed →
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Original publication title: Identification of microsatellite markers linked to progressive retinal atrophy in American Eskimo Dogs.
- Species:
- dog
Plain-English summary
A group of American Eskimo Dogs was tested to find genetic markers linked to progressive retinal atrophy (PRA), a condition that can lead to vision loss. Researchers identified specific markers on chromosome 9 that are associated with this eye disease. This discovery means that a genetic test can be developed to identify dogs that carry the gene for PRA, even before they show any symptoms. This could help owners make informed decisions about breeding and managing their pets' health.
People also search for: American Eskimo Dog eye problems · progressive retinal atrophy test for dogs · genetic testing for dog vision loss
Abstract
OBJECTIVE: To identify microsatellite markers linked to progressive retinal atrophy (PRA) in American Eskimo Dogs. SAMPLE POPULATION: Blood samples or buccal epithelial cells from 66 American Eskimo Dogs, including 53 PRA-unaffected and 13 PRA-affected dogs. PROCEDURE: The genotypes of unaffected and affected dogs were determined by use of microsatellite markers spanning canine chromosome 9 (CFA09). Homozygosity mapping was used to detect linkage between markers and the gene locus for PRA. RESULTS: Significant allelic association between marker alleles and the gene locus for PRA was detected for GALK1 and TK1, indicating linkage between these markers and the causative gene locus for PRA. CONCLUSIONS AND CLINICAL RELEVANCE: These data indicate that PRA in American Eskimo Dogs is located on CFA09 and allow for the development of a microsatellite-based test to identify carrier (unaffected) and affected dogs before clinical signs appear.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16334947/