Peer-reviewed veterinary case report
Identification of several clades of novel single-stranded circular DNA viruses with conserved stem-loop structures in pig feces.
- Journal:
- Archives of virology
- Year:
- 2015
- Authors:
- Cheung, Andrew K et al.
- Affiliation:
- Virus and Prion Diseases Research Unit · United States
Abstract
Metagenomic analysis of fecal samples collected from diarrheal swine detected sequences encoding a replication initiator protein (Rep). The genomes of ten novel single-stranded DNA viruses were determined, and they exhibited a similar genome organization. The two putative open reading frames (ORFs) encoding Rep and the capsid protein are bidirectionally transcribed and separated by two intergenic regions. Stem-loop structure(s) typical of genomes that undergo the rolling-circle DNA replication mechanism were observed. Phylogenetically, these ten genomes are in a monophyletic clade with the previously described porcine stool-associated virus (PoSCV) but are divergent enough to be further classified into to six distinct virus clades.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25248627/