Peer-reviewed veterinary case report
Idiosyncratic drug toxicity affecting the liver, skin, and bone marrow in dogs and cats.
- Journal:
- The Veterinary clinics of North America. Small animal practice
- Year:
- 2013
- Authors:
- Trepanier, Lauren A
- Affiliation:
- School of Veterinary Medicine · United States
Abstract
Idiosyncratic drug toxicity reactions are, by definition, uncommon, but can lead to serious or even fatal organ toxicity. The liver, skin, and peripheral blood cells/bone marrow are common targets. Most of these reactions are the result of reactive metabolites, which may cause local cell or organelle damage, or may be amplified by a systemic immune response. Individual risk may depend on differences in drug biotransformation, levels of oxidative stress, or antigen presentation.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23890238/