Peer-reviewed veterinary case report
IFNγ in combination with IL-7 enhances immunotherapy in two rat glioma models.
- Journal:
- Journal of neuroimmunology
- Year:
- 2013
- Authors:
- Fritzell, Sara et al.
- Affiliation:
- Department of Clinical Sciences
- Species:
- rodent
Abstract
Peripheral immunization, using a combination of interferon-gamma (IFNγ)- and interleukin-7 (IL-7)-producing tumor cells, eradicated 75% of pre-established intracerebral N32 rat glioma tumors, and prolonged survival in the more aggressive RG2 model. Rats immunized with IFNγ- and IL7-transduced N32 cells displayed increases in IFNγ plasma levels and proliferating circulating T cells when compared with rats immunized with N32-wild type cells. Following irradiation, the expression of MHC I and II was high on N32-IFNγ cells, but low on RG2-IFNγ cells. In conclusion, IFNγ and IL-7 immunizations prolong survival in two rat glioma models.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23528658/