Peer-reviewed veterinary case report
IgA nephropathy: immune mechanisms beyond IgA mesangial deposition.
- Journal:
- Kidney international
- Year:
- 2007
- Authors:
- Rifai, A
- Affiliation:
- Department of Pathology and Laboratory Medicine · United States
Abstract
IgA nephropathy is attributable to mesangial IgA immune complex deposition. The pathogenic potential of frequently colocalized IgG deposits may depend on polarized T-helper cytokines that modulate Fcgamma receptors of infiltrating macrophages, leading to either activation or inhibition that determines glomerular injury.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17653232/