Peer-reviewed veterinary case report
Fish allergy and IgE reactions in atopic dogs to Pacific cod
By Imanishi, Ichiro et al.·Published in BMC veterinary research·2020·School of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: IgE reactivity to fish allergens from Pacific cod (Gadus macrocephalus) in atopic dogs.
- Species:
- dog
Plain-English summary
A group of atopic dogs (dogs with allergies) was tested for reactions to fish proteins from Pacific cod. Out of 179 dogs, 36 showed an allergic response to cod, with 12 of those having a confirmed cod allergy. The specific proteins causing the reactions were identified, including tropomyosin and enolase. This research suggests that dogs can have similar fish allergies as humans, which could help in understanding and treating food allergies in both species.
People also search for: dog fish allergy symptoms · atopic dog treatment · Pacific cod allergy in dogs
Abstract
BACKGROUND: IgE reactivity to fish allergens in atopic dogs, which are used as models for food allergy, has not been elucidated to date. We investigated IgE reactivity to crude extracts and purified allergens derived from the Pacific cod (Gadus macrocephalus) in atopic dogs to identify the allergenic proteins of cod. RESULTS: The levels of specific IgE to crude cod extracts were measured in the sera of 179 atopic dogs, including 27 dogs with cod allergy, using enzyme-linked immunosorbent assay (ELISA). Specific IgE to crude cod extracts were present in 36 (20%) of the 179 atopic dogs and in 12 (44%) of the 27 dogs with cod allergy. The allergens in crude cod extracts were analyzed by ELISA, immunoblotting, and liquid chromatography-tandem mass spectrometry. In allergen component analysis, IgE reactivity to tropomyosin and enolase was observed in the sera of dogs with cod allergy. IgE reactivity to parvalbumin, collagen, and tropomyosin was evaluated using the sera of atopic dogs that tested positive for specific IgE to crude cod extracts. Among the 36 dogs with IgE reactivity to crude cod extracts, 9 (25%), 14 (39%), and 18 (50%) dogs tested positive for specific IgE to parvalbumin, collagen, and tropomyosin, respectively. CONCLUSIONS: The IgE reactivity to cod allergens observed in dogs was similar to that in humans, and this finding further supports the use of atopic dogs with fish allergy as a model for fish allergy in humans.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32938440/