Peer-reviewed veterinary case report
IKCa-channel blockers. Part 2: discovery of cyclohexadienes.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2005
- Authors:
- Urbahns, Klaus et al.
- Affiliation:
- Institute of Medicinal Chemistry
- Species:
- rodent
Abstract
Novel cyclohexadienes have been identified as potent and specific IK(Ca)-channel blockers. In this communication we describe their synthesis as well as their chemical and biological properties. A selected derivative is being enriched in rat brain and reduces the infarct volume, intracranial pressure as well as the water content in a rat subdural hematoma model of traumatic brain injury after iv administration.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15603962/