Peer-reviewed veterinary case report
IL-6-deficient mice show impaired inflammatory response in a model of myosin-induced experimental myositis.
- Journal:
- Journal of neuroimmunology
- Year:
- 2006
- Authors:
- Scuderi, Flavia et al.
- Affiliation:
- Institute of General Pathology · Italy
Abstract
Inflammatory/immune reactions against muscle cells are responsible for the damage in idiopathic inflammatory myopathies. We investigated the role of IL-6, a cytokine known to contribute to local leukocyte accumulation, in a model of myosin-induced experimental myositis. After injection of rabbit myosin in CFA/pertussis toxin, normal mice develop clinically evident muscle deficit and damage, as demonstrated by myofiber necrosis and leukocyte infiltration, while IL-6-deficient mice have no clinical or histological signs of muscle damage. This study evidences that selective deficiency of IL-6 directly or indirectly hinders the local inflammatory response and its harmful effects in this model of muscle damage.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16725212/