Peer-reviewed veterinary case report
Ileal mucosal and fecal pancreatitis associated protein levels reflect severity of salmonella infection in rats.
- Journal:
- Digestive diseases and sciences
- Year:
- 2009
- Authors:
- van Ampting, Marleen T J et al.
- Affiliation:
- TI Food and Nutrition · Netherlands
- Species:
- rodent
Abstract
BACKGROUND: Microbial infections induce ileal pancreatitis-associated protein/regenerating gene III (PAP/RegIII) mRNA expression. Despite increasing interest, little is known about the PAP/RegIII protein. Therefore, ileal mucosal PAP/RegIII protein expression, localization, and fecal excretion were studied in rats upon Salmonella infection. RESULTS: Salmonella infection increased ileal mucosal PAP/RegIII protein levels in enterocytes located at the crypt-villus junction. Increased colonization and translocation of Salmonella was associated with higher ileal mucosal PAP/RegIII levels and secretion of this protein in feces. CONCLUSIONS: PAP/RegIII protein is increased in enterocytes of the ileal mucosa during Salmonella infection and is associated with infection severity. PAP/RegIII is excreted in feces and might be used as a new and non-invasive infection marker.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19160051/