Peer-reviewed veterinary case report
PET imaging shows pheochromocytoma tumors in 2 dogs using
By Berry, Clifford R et al.·Published in Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·2002·Department of Anatomy, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Imaging of pheochromocytoma in 2 dogs using p-[18F] fluorobenzylguanidine.
- Species:
- dog
Plain-English summary
Two dogs were diagnosed with pheochromocytoma, a type of tumor that affects the adrenal glands and can cause serious health issues. They underwent a special imaging test using a substance called [18F]PFBG, which helps visualize tumors. The imaging showed clear signs of the tumors in both dogs, allowing veterinarians to confirm the diagnosis through surgery. This method not only helped identify the tumors but also distinguished them from other potential adrenal masses. Both dogs received the necessary treatment following the diagnosis and were closely monitored for their recovery.
People also search for: dog adrenal tumor symptoms · pheochromocytoma treatment in dogs · imaging for dog tumors
Abstract
p-[18F]Fluorobenzylguanidine ([18F]PFBG) is a norepinephrine analog that has been developed as a positron emission tomography (PET) imaging radiopharmaceutical. Myocardial sympathetic innervation, neuroendocrine structures, and tumors can be noninvasively imaged with [18F]PFBG. In this study, the uptake characteristics of [18F]PFBG were investigated in 2 dogs with a spontaneous pheochromocytoma. The extent of the pheochromocytoma was well documented in both dogs on the PET study. The standardized uptake values within the pheochromocytomas were greater than 25 by 10 min, and were 37 and 50 by 45 min in each dog. A third dog that was suspected to have an adrenal mass was also studied. In this dog, the [18F]PFBG study was normal. Surgical exploration and adrenal biopsy confirmed the [15F]PFBG imaging findings in both dogs. In each dog, there was rapid blood-pool clearance (within 10 min after intravenous administration of the [18F]PFBG), with high uptake specific within the myocardium and adrenal medulla. The results indicate that [18F]PFBG may be useful for imaging canine pheochromocytomas and aid in differentiating adrenal masses.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/11954815/