Peer-reviewed veterinary case report
Dog with stomach tumor and c-kit mutation shrinks tumor
By Kobayashi, Masato et al.·Published in Veterinary journal (London, England : 1997)·2013·Department of Veterinary Clinical Pathology, Japan·View original on PubMed →
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Original publication title: Imatinib-associated tumour response in a dog with a non-resectable gastrointestinal stromal tumour harbouring a c-kit exon 11 deletion mutation.
- Species:
- dog
Plain-English summary
A 10-year-old female Miniature Dachshund was diagnosed with a non-removable gastrointestinal stromal tumor and started on a medication called imatinib. After 21 days of treatment, the tumor began to shrink, and it continued to decrease in size for about two months. Although the tumor size stabilized after that, it did not grow larger over the next several months. This case shows that imatinib can be effective for certain tumors with specific genetic mutations, leading to a positive response in this dog.
People also search for: dog gastrointestinal tumor treatment · Miniature Dachshund cancer medication · imatinib for dogs tumor response
Abstract
A 10-year-old female Miniature Dachshund with a non-resectable gastrointestinal stromal tumour was treated with imatinib. The neoplastic cells had a deletion mutation (c.1667_1672del) within exon 11 of the c-kit gene, which resulted in deletion of three amino acids and insertion of one amino acid (p.Trp556_Val558delinsPhe) in the juxtamembrane domain of KIT. Following treatment with imatinib, the dog achieved partial remission on Day 21 with a continuous decrease in tumour size until Day 67 of treatment. Although no additional decrease in size was observed after Day 67 of treatment, the tumour remained stable in size as of Day 140 of treatment. The c-kit mutation found in the tumour cells appears to be a mutation driving oncogenesis, as evidenced by the partial remission elicited by imatinib in this dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23820134/