Peer-reviewed veterinary case report
Dog with recurring gut tumor and c-kit mutation cured by imatinib
By Irie, Mitsuhiro et al.·Published in The Journal of veterinary medical science·2015·Shikoku Veterinary Medical Center, Japan·View original on PubMed →
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Original publication title: Imatinib mesylate treatment in a dog with gastrointestinal stromal tumors with a c-kit mutation.
- Species:
- dog
Plain-English summary
A 13-year-old spayed mixed-breed dog was diagnosed with a gastrointestinal stromal tumor (GIST) after a mass was found in her abdomen. Unfortunately, the tumor came back five months after surgery, and tests showed a mutation in a gene linked to this type of cancer. The vet started her on a targeted treatment called imatinib mesylate, and after two months, the dog was in complete remission. This suggests that some dogs with GIST may respond well to this type of therapy.
People also search for: dog abdominal mass treatment · gastrointestinal stromal tumor in dogs · imatinib for dog cancer
Abstract
A 13-year-old spayed mixed-breed dog was diagnosed with a gastrointestinal stromal tumor (GIST) after histopathological examination of an abdominal mass. Five months after surgical resection of the tumor, we detected the recurrence of GIST with multiple disseminated abdominal lesions. A sequence analysis of cDNA obtained from a biopsy of the recurrent tumors revealed a mutation within exon 9 of the c-kit gene (1523A>T, Asn(508)Ile), which has been shown to cause ligand-independent phosphorylation of the KIT protein in GISTs and canine mast cell tumors (MCTs). Upon detection of the recurrent tumors, we initiated treatment with imatinib mesylate (10 mg/kg, q 24 hr). After 2 months, the dog achieved complete remission. Our findings indicate that canine GIST, and possibly MCT, may be responsive to molecular-targeted therapy.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26074249/