Peer-reviewed veterinary case report
Imatinib treatment success in dogs with new mast cell tumor mutations
By Nakano, Yuko et al.·Published in The Journal of veterinary medical science·2014·Japan Small Animal Cancer Center, Japan·View original on PubMed →
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Original publication title: Imatinib responsiveness in canine mast cell tumors carrying novel mutations of c-KIT exon 11.
- Species:
- dog
Plain-English summary
A 9-year-old dog with a mast cell tumor was treated with imatinib mesylate, a medication commonly used for this type of cancer. The treatment led to complete remission of the tumor within just two weeks. However, the remission period varied, lasting about 66 days for one tumor and 255 days for the other before the tumor began to return. While the specific mutations in the tumor cells were not fully understood, the treatment showed promising results in managing the condition.
People also search for: dog mast cell tumor treatment · imatinib for dog cancer · mast cell tumor remission in dogs
Abstract
In 2 individual cases of canine mast cell tumors, we identified 2 novel c-KIT mutations in exon 11: a 9-base pair (bp) deletion (c.1663-1671del) and a point mutation (c.1676T>A). The 9-bp deletion mutation caused a loss of 3 amino acids, corresponding to p.Gln555_Lys557del, and the point mutation resulted in the substitution of valine by aspartic acid (p.Val559Asp) in the juxtamembrane domain of the protein. Imatinib mesylate, a therapeutic agent for canine mast cell tumors, was used to treat both tumors. Complete remission was achieved at 33 and 14 days after administration, respectively. However, in both cases, the therapeutic response subsequently tapered with the duration of remission lasting 66 and 255 days, respectively. Although these 2 novel c-KIT mutations in exon 11 were not confirmed to be gain-of-function mutations, a further study may help clarify relevance between mutations identified in this report and responsiveness.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24292246/