Peer-reviewed veterinary case report
Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2011
- Authors:
- Dyckman, Alaric J et al.
- Affiliation:
- Bristol-Myers Squibb · United States
Abstract
The synthesis, structure-activity relationships (SAR) and biological evaluation of thiazole based tricyclic inhibitors of IKK2 are described. Compound 9 was determined to be orally efficacious in a murine model of rheumatoid arthritis.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21087862/