Peer-reviewed veterinary case report
Immobilization of actively thromboresistant assemblies on sterile blood-contacting surfaces.
- Journal:
- Advanced healthcare materials
- Year:
- 2014
- Authors:
- Qu, Zheng et al.
- Affiliation:
- Department of Surgery · United States
Abstract
Rapid one-step modification of thrombomodulin with alkylamine derivatives such as azide, biotin, and PEG is achieved using an evolved sortase (eSrtA) mutant. The feasibility of a point-of-care scheme is demonstrated herein to site-specifically immobilize azido-thrombomodulin on sterilized commercial ePTFE vascular grafts, which exhibit superior thromboresistance compared with commercial heparin-coated grafts in a primate model of acute graft thrombosis.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23788402/