Peer-reviewed veterinary case report
Immune Imprinting in the Influenza Ferret Model
- Journal:
- Vaccines
- Year:
- 2020
- Authors:
- Skarlupka, Amanda L. & Ross, Ted M.
- Affiliation:
- Center for Vaccines and Immunology, University of Georgia, Athens, GA 30602, USA · United States
- Species:
- rodent
Abstract
The initial exposure to influenza virus usually occurs during childhood. This imprinting has long-lasting effects on the immune responses to subsequent infections and vaccinations. Animal models that are used to investigate influenza pathogenesis and vaccination do recapitulate the pre-immune history in the human population. The establishment of influenza pre-immune ferret models is necessary for understanding infection and transmission and for designing efficacious vaccines.
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Search related cases →Original publication: https://doi.org/10.3390/vaccines8020173