Peer-reviewed veterinary case report
Immune anemia and red cell failure in Jack Russell on adrenal
By Yokota, Shunya & Yuki, Masashi·Published in Veterinary clinical pathology·2024·Yuki Animal Hospital, Japan·View original on PubMed →
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Original publication title: Immune-mediated hemolytic anemia and pure red cell aplasia in a Jack Russell Terrier during treatment for hypoadrenocorticism.
- Species:
- dog
Plain-English summary
An 11-year-old neutered male Jack Russell Terrier was brought to the vet for anemia while being treated for low adrenal function (hypoadrenocorticism). Tests showed that his body was destroying red blood cells (immune-mediated hemolytic anemia or IMHA), and despite treatment with medications like prednisolone, his condition worsened, leading to a lack of red blood cell production (pure red cell aplasia or PRCA). Unfortunately, even with immunosuppressive treatment, the dog developed complications and passed away due to thrombosis. This case highlights a rare connection between these serious conditions.
People also search for: Jack Russell Terrier anemia treatment · IMHA in dogs · pure red cell aplasia in dogs
Abstract
An 11-year-old neutered male Jack Russell Terrier was presented to Yuki Animal Hospital for regenerative anemia during the treatment of hypoadrenocorticism. A blood smear examination showed spherocytes, polychromatic erythrocytes, and erythrocyte ghosts. The direct agglutination test was positive at 37°C. The dog was then diagnosed with immune-mediated hemolytic anemia (IMHA). Although prednisolone and mycophenolate mofetil were administered, the hematocrit and reticulocyte count decreased, and nonregenerative anemia developed. A bone marrow examination was performed to diagnose the cause of the nonregenerative anemia. Histologic and cytologic bone marrow examination revealed a normocellular to hypercellular medulla with severe erythroid hypoplasia. No proliferation of lymphocytes or lymphoblast-appearing cells was observed. This dog was diagnosed with pure red cell aplasia (PRCA). Despite treatment with immunosuppressive agents, the patient died of thrombosis. Although these associations were unclear, this is the first report of PRCA diagnosis following IMHA and while treating hypoadrenocorticism.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38433116/