Peer-reviewed veterinary case report
Immune response and viral persistence in Indian buffaloes (Bubalus bubalis) infected with foot-and-mouth disease virus serotype Asia 1.
- Journal:
- Clinical and vaccine immunology : CVI
- Year:
- 2009
- Authors:
- Maddur, Mohan S et al.
- Affiliation:
- Indian Veterinary Research Institute · India
Abstract
Despite their potential role in the spread of foot-and-mouth disease (FMD), the immune response and viral persistence in FMD virus (FMDV)-infected Indian buffaloes (Bubalus bubalis) have been unexplored. We found similar kinetics of neutralizing antibody responses in the sera and secretory fluids of buffaloes following experimental FMDV Asia 1 infection, but the lymphocyte-proliferative response in infected buffaloes was of low magnitude. Despite inducing a significant systemic and secretory immune response, viral persistence seems to be a common outcome in buffaloes following FMDV Asia 1 infection, which is associated with a weak cellular immune response.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19828770/