Peer-reviewed veterinary case report
Immune response in beagle dogs after leptospira vaccine and challenge
By Arjoonsingh, Virmal et al.·Published in Veterinary immunology and immunopathology·2023·The University of the West Indies·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Immune response at a vaccine-challenge study using beagle dogs and locally isolated Leptospira spp.
- Species:
- dog
Plain-English summary
A group of beagle dogs was vaccinated with a killed Leptospira vaccine and then exposed to a strain of Leptospira to see how well the vaccine worked. After the challenge, the vaccinated dogs had higher antibody levels and did not show signs of infection in their urine, while the unvaccinated dogs did. Although the vaccine did not completely prevent the bacteria from entering the bloodstream, it effectively stopped the bacteria from being present in the urine. This suggests that the vaccine can help protect dogs from certain effects of leptospirosis, a serious infection caused by these bacteria.
People also search for: dog leptospirosis vaccine · beagle dog vaccination · leptospira infection symptoms in dogs
Abstract
Determination of the immune response of dogs by measuring the antibody levels (utilizing MAT) and levels of cytokines (TNF-α, IL-4 and IFN-γ) post-vaccination with locally produced killed whole-celled Leptospiral vaccine and post-challenge with a locally isolated Leptospira icterohaemorrhagiae Copenhageni strain. For assessment of immunity of the vaccine serum antibodies were detected before and after vaccination and challenge in three studies. The effects of the challenge were determined by a variety of parameters including reisolation of the challenge Leptospira spp. via blood, urine, and kidney samples. The challenge strain did not produce generalised infection but elevated circulating antibody levels in both the control and vaccinated dogs in any of the three studies, however leptospires were reisolated from the urine of the control dogs but not the vaccinated dogs. Cytokine levels (TNF-α, IFN-γ and IL-4) were detected post-challenge in the vaccinated dogs to determine the immune profile response. The whole-killed cell vaccine in this study did not prevent leptospireamia but prevented leptospiruria in vaccinated dogs after a challenge with a live Leptospira icterohaemorrhagiea Copenhageni. The vaccine-challenge showed increased antibody (MAT) levels due to vaccination and infection (through challenge). Cytokine production (TNF-α, IFN-γ and IL-4) by the host immune system was observed post-challenge with live leptospires.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36481533/