Peer-reviewed veterinary case report
Vaccine with Babesia rossi and canis antigens protects dogs
By Schetters, Th P M et al.·Published in Veterinary parasitology·2007·Parasitology R&D Department, Netherlands·View original on PubMed →
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Original publication title: Immunity against Babesia rossi infection in dogs vaccinated with antigens from culture supernatants.
- Species:
- dog
Plain-English summary
A group of dogs was vaccinated with a new vaccine made from proteins from two types of parasites, Babesia rossi and Babesia canis, to see if it could protect them from infection. The vaccinated dogs showed fewer symptoms and had no signs of the parasites in their blood after receiving three doses of the vaccine. In contrast, most of the unvaccinated dogs became seriously ill and needed medication to survive. While the vaccine didn't completely prevent mild anemia, it effectively protected the vaccinated dogs from severe infection.
People also search for: dog Babesia vaccine · symptoms of Babesia infection in dogs · treatment for Babesia in dogs
Abstract
Soluble parasite antigens (SPA) from different Babesia species have been shown earlier to induce protective immunity when used as vaccine. However, initial attempts to produce such vaccine against Babesia rossi infection using SPA from B. rossi culture supernatants were not or only partially successful. Here we show that when dogs were vaccinated with a vaccine comprising SPA from B. rossi combined with SPA from Babesia canis protective immunity against experimental challenge infection was induced. Immunity was reflected in reduced clinical signs that resolved spontaneously, and reduction of parasitaemia and SPA in the blood. Not a single infected erythrocyte could be found in blood smears of dogs that had been repeatedly boosted (three vaccinations in total). In contrast, three out of four control dogs required chemotherapeutic treatment to prevent death. The fourth control dog showed a transient parasitaemia that resolved spontaneously. Vaccination did not prevent the development of a transient anaemia. It is concluded that a vaccine containing a mixture of SPA obtained from in vitro culture supernatants of B. rossi and B. canis induces protection in dogs against heterologous challenge infection with B. canis (as shown before) or B. rossi.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17056181/