Peer-reviewed veterinary case report
Puppies with mom's antibodies protected by canarypox distemper vaccine
By Pardo, M C et al.·Published in Journal of comparative pathology·2007·Biological Research and Development, United States·View original on PubMed →
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Original publication title: Immunization of puppies in the presence of maternally derived antibodies against canine distemper virus.
- Species:
- dog
Plain-English summary
A group of 12 puppies, aged 7 to 9 weeks, were vaccinated against canine distemper virus (CDV) even though they had some immunity from their mothers. After receiving the vaccine, these puppies were protected when exposed to the virus, showing that the vaccine worked well despite the maternal antibodies. In contrast, three unvaccinated littermates developed serious symptoms after being exposed to the virus, and two of them sadly died. This study highlights the importance of vaccinating puppies to ensure their safety against distemper.
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Abstract
Vaccination of dams with modified-live canine distemper virus (CDV) vaccines will elicit high concentrations of colostral antibody, that although vital for protection of the pup during the first weeks of life, can interfere with active vaccination against the virus. In the present study, 12 pups, 7-9 weeks of age, with maternally derived immunity to CDV, were vaccinated with a canarypox-vectored CDV vaccine. These pups were protected against intravenous challenge with CDV. Three littermate pups that were unvaccinated all developed clinical signs of infection after challenge, and two of these control pups died.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17560592/