Peer-reviewed veterinary case report
Allergic reactions in dogs linked to fetal calf serum in vaccines
By Ohmori, Keitaro et al.·Published in Veterinary immunology and immunopathology·2007·Department of Veterinary Internal Medicine, Japan·View original on PubMed →
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Original publication title: Immunoblot analysis for IgE-reactive components of fetal calf serum in dogs that developed allergic reactions after non-rabies vaccination.
- Species:
- dog
Plain-English summary
A group of dogs developed allergic reactions after receiving vaccinations, and researchers found that their blood contained IgE antibodies reacting to proteins in fetal calf serum (FCS), which is used in some vaccines. In a study of 16 dogs, several proteins from FCS were identified as potential allergens, with one specific protein (about 66-kDa in size) being present in most of the dogs' blood samples. This suggests that components of FCS, including a type of albumin, may trigger allergic reactions in some dogs after vaccination. Understanding these allergens can help veterinarians manage and prevent future allergic responses in dogs.
People also search for: dog allergic reaction after vaccination · dog vaccine allergy symptoms · what to do if my dog has an allergic reaction
Abstract
We previously demonstrated the presence of IgE directed to fetal calf serum (FCS) in the sera from dogs that developed allergic reactions after vaccination. In this study, by an immunoblot analysis, we investigated the IgE-reactive components of FCS using sera from 16 dogs that exhibited allergic reactions after vaccination. The immunoblot analysis revealed that several FCS proteins of approximately 25-, 50-, 66-, 75-, 120-, and 175-kDa strongly reacted with IgE in the sera from dogs that showed post-vaccination allergic reactions. The 66-kDa band was detected in the sera from 14 of the 16 dog serum samples analyzed in the immunoblot analysis for FCS, and it was speculated to be albumin based on its molecular weight; however, serum IgE reactivity to bovine serum albumin could be detected in only four of the 14 dog samples. These findings demonstrated that a variety of FCS components including albumin could function as allergens in dogs that developed allergic reactions after vaccination.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17118462/