Peer-reviewed veterinary case report
Dog vaccine using DNA and virus to fight Babesia gibsoni infection
By Fukumoto, Shinya et al.·Published in Experimental parasitology·2009·Obihiro University of Agriculture and Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Immunogenicity and growth inhibitory efficacy of the prime-boost immunization regime with DNA followed by recombinant vaccinia virus carrying the P29 gene of Babesia gibsoni in dogs.
- Species:
- dog
Plain-English summary
A group of dogs was given a special vaccination to help protect them from Babesia gibsoni, a parasite that can cause serious illness. They received a DNA vaccine followed by a booster shot with a viral vaccine. After the vaccinations, these dogs showed a strong immune response and had lower levels of the parasite in their blood compared to those who didn't receive the vaccine. This approach appears to be effective in helping dogs fight off this infection.
People also search for: dog Babesia gibsoni vaccine · canine parasite prevention · dog vaccination immune response
Abstract
In recent studies, heterologous prime-boost approaches, employing plasmid DNA and viral vector pathogen-delivering sequences, have been considered an effective protection strategy for intracellular parasite infections. Here, we evaluated the efficacy of such a strategy against the canine Babesia gibsoni infection. The DNA (pCAGGS-P29) and recombinant vaccinia virus (vvP29) both encoding the P29 of B. gibsoni were used in this study. The dogs were immunized 3 times with priming DNA and boosted once with recombinant virus. The dogs immunized with P29 developed a significant level of IgG2 antibody against P29. The response was strongly boosted by the inoculation of vvP29. The peripheral IFN-gamma responses of the dogs immunized with P29 were significantly higher than those of controls after the parasite inoculation. Moreover, the P29 immunized group showed a significantly low level of parasitemia. In conclusion, this study supports the efficacy of a prime-boost strategy for dogs against canine B. gibsoni infection.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19712674/