Peer-reviewed veterinary case report
Bivalent vaccine tested for feline herpes and rabies in cats and mice
By Jiao, Cuicui et al.·Published in Veterinary journal (London, England : 1997)·2024·Institute of Zoonosis, China·View original on PubMed →
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Original publication title: Immunogenicity evaluation of a bivalent vaccine based on a recombinant rabies virus expressing gB protein of FHV-1 in mice and cats.
- Species:
- cat
Plain-English summary
A group of cats was given a new vaccine designed to protect against both feline herpesvirus-1 (FHV-1), which causes upper respiratory issues, and rabies. After receiving three doses of this bivalent vaccine, the cats developed strong immune responses, producing antibodies that can fight off both viruses. This vaccine could help prevent serious illness or death in vulnerable cats, such as kittens or those with weakened immune systems. The study shows promise for creating effective vaccines that target multiple diseases in cats.
People also search for: cat vaccine for herpesvirus · rabies vaccine for cats · feline upper respiratory infection treatment
Abstract
Feline viral rhinotracheitis (FVR) is caused by the feline herpesvirus-1 (FHV-1), which commonly results in upper respiratory symptoms, and can result in death in the kittens and weak cats. Rabies is an infectious disease with zoonotic characteristics highly relevant to public health and also poses a serious threat to cats. Vaccines are the most effective method to control the spread of both FHV-1 and RABV and have the advantage that they produce long-term specific immune responses. In this study, we constructed a bivalent vaccine against FHV-1 and rabies virus (RABV) simultaneously. The vaccine was constructed by cloning FHV-1 gB into a RABV based vector, and the recombinant RABV (SRV9-FHV-gB) expressing the FHV-1 gB protein was rescued. The growth characteristics of SRV9-FHV-gB were analyzed on NA and BSR cells. To assess the immunogenicity of the vaccine, mice and cats were immunized with SRV9-FHV-gB supplemented with Gel02 adjuvant. The SRV9-FHV-gB exhibited the same growth characteristics as the parent virus SRV9 in both BSR cells and NA cells. The safety of SRV9-FHV-gB was evaluated using 5-day-old and 14-day-old suckling mice. The results showed that mice infected with the SRV9-FHV-gB survived for longer than those in the SRV9 group. Mice immunized with inactivated SRV9-FHV-gB produced high titers of specific antibodies against FHV-1 and neutralizing antibodies against RABV. Cats that received three immunizations with SRV9-FHV-gB also produced neutralizing antibodies against both FHV-1 and RABV. This study represents the first time that a bivalent vaccine targeting FHV-1 and RABV has been constructed, laying the foundations and providing inspiration for the development of other multivalent vaccines.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38503385/