Peer-reviewed veterinary case report
Immunogenicity of Helicobacter pylori urease B protein and DNA vaccines in a mouse model.
- Journal:
- Journal of pediatric gastroenterology and nutrition
- Year:
- 2007
- Authors:
- Bégué, Rodolfo E et al.
- Affiliation:
- Department of Pediatrics · United States
- Species:
- rodent
Abstract
A vaccine could alleviate major morbidity and mortality associated with Helicobacter pylori infection. We immunized BALB/c mice with 3 doses of a protein or DNA vaccine based on H pylori urease B. Protein alone was immunogenic even after the first dose, whereas DNA did not elicit antibodies after 3 doses. DNA preceding protein (D-P-P) appeared to blunt the response to protein, whereas DNA following protein (P-D-D) shifted from a predominantly T helper 2 (Th2) profile to a balanced Th1:Th2 profile. These preliminary findings may have important implications for the development of an H pylori vaccine.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18030223/