Peer-reviewed veterinary case report
Immunoglobulin G4-related disease diagnosed and treated in a dog
By Colopy, Lydia J et al.·Published in Journal of veterinary internal medicine·2019·Veterinary Emergency Service·View original on PubMed →
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Original publication title: Immunoglobulin G4-related disease in a dog.
- Species:
- dog
Plain-English summary
An 8-year-old female spayed Husky mix was diagnosed with a rare condition called Immunoglobulin G4-related disease (IgG4-RD), which can cause swelling and other vague symptoms in dogs. The dog showed signs of swelling and had elevated levels of certain antibodies in her blood. After careful diagnosis, the veterinarian successfully treated her condition, leading to an improvement in her symptoms. This case highlights the importance of considering IgG4-RD in dogs that present with unusual signs and swelling.
People also search for: dog swelling treatment · Husky mixed breed health issues · dog immune system disease
Abstract
Immunoglobulin G4-related disease (IgG4-RD), which affects many organ systems, has been recognized as a distinct clinical entity in human medicine for just over a decade but has not been previously identified in dogs. In humans, IgG4-RD is characterized by diffuse IgG4-positive lymphoplasmacytic infiltrates that commonly lead to increased serum concentrations of IgG4 and IgE, peripheral eosinophilia, tumorous swellings that often include the parotid salivary glands, obliterative phlebitis, and extensive fibrosis. Herein we describe the diagnosis, clinical progression, and successful treatment of IgG4-RD in an 8-year-old female spayed Husky mixed breed dog. Immunoglobulin G4-related disease should be considered as a differential diagnosis for dogs with vague clinical signs, lymphoplasmacytic swellings, restricted polyclonal gammopathy, eosinophilia or some combination of these findings.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31654456/