Peer-reviewed veterinary case report
Amyloidosis in horses - what you need to know
By Linke, R P & Trautwein, G·Published in Blut·1989·Institut fü, Germany·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Immunoglobulin lambda-light-chain-derived amyloidosis (A lambda) in two horses.
- Species:
- horse
Plain-English summary
In this study, researchers looked at two horses that had unusual deposits of a protein called amyloid in their nasal tissue. These deposits were different from a more common type of amyloidosis seen in horses, both in how they affected the horses and how they responded to a specific treatment. By using special tests, the scientists identified that the amyloid in these horses was a different type known as A lambda. This finding suggests that there is another form of amyloidosis in horses, which can also occur in animals, not just humans.
Abstract
Tumorous amyloid deposits in the nasal mucosa of two horses differed from generalized AA-amyloidosis with respect to clinical features, organ distribution, and resistance to KMnO4 treatment. Using a panel of antibodies directed against different human amyloid fibril proteins and employing the peroxidase-anti-peroxidase (PAP) technique, we showed the described equine amyloid to be A lambda-type, as demonstrated by immunohistochemical cross-reactivity. Consequently, we identified a second amyloid class in horses and showed that immunoglobulin light-chain-derived amyloid may also be present in animals.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/2495038/