Peer-reviewed veterinary case report
Immunoglobulin lambda-light-chain-derived amyloidosis (A lambda) in two horses.
- Journal:
- Blut
- Year:
- 1989
- Authors:
- Linke, R P & Trautwein, G
- Affiliation:
- Institut fü · Germany
- Species:
- horse
Plain-English summary
In this study, researchers looked at two horses that had unusual deposits of a protein called amyloid in their nasal tissue. These deposits were different from a more common type of amyloidosis seen in horses, both in how they affected the horses and how they responded to a specific treatment. By using special tests, the scientists identified that the amyloid in these horses was a different type known as A lambda. This finding suggests that there is another form of amyloidosis in horses, which can also occur in animals, not just humans.
Abstract
Tumorous amyloid deposits in the nasal mucosa of two horses differed from generalized AA-amyloidosis with respect to clinical features, organ distribution, and resistance to KMnO4 treatment. Using a panel of antibodies directed against different human amyloid fibril proteins and employing the peroxidase-anti-peroxidase (PAP) technique, we showed the described equine amyloid to be A lambda-type, as demonstrated by immunohistochemical cross-reactivity. Consequently, we identified a second amyloid class in horses and showed that immunoglobulin light-chain-derived amyloid may also be present in animals.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/2495038/