Peer-reviewed veterinary case report
Immunohistochemical Analysis of Programmed Death-Ligand 1 Expression in Equine Sarcoids.
- Journal:
- Journal of equine veterinary science
- Year:
- 2021
- Authors:
- Benvegnen, Jennifer et al.
- Affiliation:
- Institute of Animal Pathology
- Species:
- horse
Abstract
The aim of the study was to assess the expression of the immune checkpoint inhibitor programmed death-ligand 1 (PD-L1) in equine sarcoids (ES). Programmed death-ligand 1 is expressed by various cancer cells to block T cell-mediated elimination of tumor cells. Antibodies targeting human PD-L1 were tested by immunohistochemistry for their cross-reactivity with equine PD-L1 using formalin-fixed, paraffin-embedded tissues. Our results do not support an important role of PD-L1-mediated immune evasion in ES disease and hence do not offer a rationale for anti-PD-1/PD-L1-based immunotherapy against ES.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/33478763/