Peer-reviewed veterinary case report
Oxidative kidney damage in older cats with chronic kidney disease
By Kurahara, Natsume et al.·Published in Journal of comparative pathology·2023·Joint Faculty of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Immunohistochemical analysis of renal oxidative damage in senior and geriatric cats with chronic kidney disease.
- Species:
- cat
Plain-English summary
A group of older cats, over 10 years old, with chronic kidney disease (CKD) were studied to understand kidney damage caused by oxidative stress. Researchers found signs of oxidative damage in the kidneys of both azotaemic (high levels of waste in the blood) and non-azotaemic cats. This suggests that oxidative stress affects the kidneys of senior cats with CKD, regardless of their waste levels. The findings highlight the importance of managing oxidative stress in older cats with kidney issues.
People also search for: cat kidney disease symptoms · senior cat kidney health · oxidative stress in cats
Abstract
Oxidative stress is a well-known cause of chronic kidney disease (CKD). In this study, renal oxidative damage in azotaemic and non-azotaemic aged cats with naturally occurring CKD was investigated using immunohistochemistry for 8-hydroxy-2'-deoxyguanosine (8-OHdG) and 4-hydroxynonenal (4-HNE) as markers of oxidative tissue damage. Kidneys were obtained from aged (>10 years old) azotaemic (n = 13) and non-azotaemic (n = 7) cats. Immunoreactivity for 8-OHdG was found in the nuclei of glomeruli, proximal and distal tubules, loops of Henle and collecting ducts, whereas 4-HNE-positive signals were detected in the cytoplasm of distal nephrons in azotaemic and non-azotaemic cats. Quantitative analysis did not identify any significant differences between the azotaemic and non-azotaemic groups for any of the parameters examined. These results indicate that renal oxidative damage occurs in the kidneys of aged cats with CKD, regardless of whether they are azotaemic or non-azotaemic, emphasizing the importance of oxidative stress during early-stage CKD in senior and geriatric cats.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37871535/