Peer-reviewed veterinary case report
Malignant intestinal carcinoid tumor with metastases in a Shih Tzu dog
By Sako, T et al.·Published in Veterinary pathology·2003·Department of Veterinary Pathology, Japan·View original on PubMed →
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Original publication title: Immunohistochemical evaluation of a malignant intestinal carcinoid in a dog.
- Species:
- dog
Plain-English summary
A 5-year-old male Shih Tzu was brought to the vet because he was very tired, not eating, vomiting, and had diarrhea and intestinal bleeding. After tests, the vet found a yellowish-white tumor in his intestines and several smaller tumors in other organs, indicating that the cancer had spread. The dog had a high level of serotonin in his blood, which is often associated with this type of cancer. Unfortunately, due to the advanced stage of the disease, treatment options were limited, and the prognosis was poor.
People also search for: dog intestinal cancer symptoms · Shih Tzu vomiting and diarrhea · malignant carcinoid treatment for dogs
Abstract
An intestinal carcinoid with multiple metastases was identified in a 5-year-old male Shih Tzu with a clinical history of anemia, fatigue, anorexia, vomiting, intermittent diarrhea, intestinal bleeding, and progressive emaciation. There was a yellowish-white mass 15 mm in diameter in the anterior jejunum and white nodules consistent with metastases in many organs. Histopathologically, the mass consisted of neoplastic cells arranged in lobules, trabeculae, or closely interdigitating islands of cells. Neoplastic cells were generally polygonal with round hyperchromatic nuclei, modest amounts of eosinophilic cytoplasm, and eosinophilic cytoplasmic granules. Mitoses were common. Rosette formations of tumor cells were apparent in metastatic tumors. Immunohistochemically, tumor cells stained positive for cytokeratin 13, synaptophysin, protein gene product 9.5, neuron-specific enolase, chromogranin A, calcitonin gene-related peptide, serotonin (5-HT), and Leu-7. Serum 5-HT concentrations for this dog were increased 10-fold compared with those of normal dogs. All findings were consistent with a diagnosis of a malignant intestinal carcinoid.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/12637763/