Peer-reviewed veterinary case report
Protein markers p63, Ki67, and beta-catenin in dog bladder cancer
By Hanazono, K et al.·Published in Veterinary and comparative oncology·2016·Department of Small Animal Clinical Sciences, Japan·View original on PubMed →
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Original publication title: Immunohistochemical expression of p63, Ki67 and β-catenin in canine transitional cell carcinoma and polypoid cystitis of the urinary bladder.
- Species:
- dog
Plain-English summary
A study looked at dogs with transitional cell carcinoma (TCC), a serious bladder tumor, to find out if certain proteins could help predict how aggressive the cancer is and how long the dog might live. They found that low levels of the protein p63 were linked to worse outcomes, including the spread of cancer and shorter survival times. In contrast, higher levels of another protein, Ki67, were found in TCC compared to normal bladders. This suggests that measuring p63 could help veterinarians assess the prognosis for dogs diagnosed with TCC.
People also search for: dog bladder cancer treatment · transitional cell carcinoma in dogs · p63 protein in canine cancer · dog urinary bladder tumor prognosis
Abstract
Transitional cell carcinoma (TCC) is a urinary bladder tumour associated with high mortality in dogs. In this study, we investigated the feasibility of using p63, Ki67 or β-catenin as a clinical marker for predicting biological behaviour and prognosis in canine TCC. Expression levels of these proteins in TCC (n = 25), polypoid cystitis (n = 5) and normal urinary bladder (n = 5) were scored after immunohistochemical staining. The staining scores for p63 (P < 0.01) and β-catenin (P < 0.05) in TCC were significantly lower than those in normal urinary bladder and polypoid cystitis. In contrast, Ki67 (P < 0.01) staining scores in TCC were significantly higher than those in normal urinary bladder and polypoid cystitis. In TCC, low p63 expression was significantly related to the presence of vessel invasion (P < 0.05) and metastasis (P < 0.01) as well as short survival time (P < 0.05). These findings show that p63 could be a reliable marker for predicting prognosis in canine TCC.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24758385/