Peer-reviewed veterinary case report
OCT4 protein found in dog mast cell tumors but not linked to survival
By Vargas, T H M et al.·Published in Journal of comparative pathology·2015·Laborató, Brazil·View original on PubMed →
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Original publication title: Immunohistochemical Expression of the Pluripotency Factor OCT4 in Canine Mast Cell Tumours.
- Species:
- dog
Plain-English summary
A group of dogs with mast cell tumors (a type of skin cancer) was studied to see if a specific protein called OCT4 could help predict how the cancer would behave. The dogs were treated with surgery and monitored for at least six months. The results showed that the presence of OCT4 did not provide clear information about the severity of the tumors or the dogs' chances of survival after surgery. Overall, the study suggests that OCT4 may not be a reliable indicator for mast cell tumors in dogs.
People also search for: dog mast cell tumor prognosis · mast cell tumor treatment in dogs · what is OCT4 in dog cancer
Abstract
Cancer stem cells (CSCs) are related to malignancy and resistance to chemotherapy in several tumours. OCT4 is a 'pluripotency factor' that is expressed by these cells. The aim of the present study was to investigate OCT4 expression in canine cutaneous mast cell tumours (MCTs) by means of immunohistochemistry. Twenty-eight cases were evaluated and showed variable immunolabelling patterns. The dogs were treated by surgery alone and followed up for a minimum of 180 days. No significant difference was found between histopathological grades and similar results were obtained for mortality due to the disease and post-surgical survival. These preliminary results suggest that OCT4 expression is not a precise prognostic indicator for canine MCT.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26460092/