Peer-reviewed veterinary case report
Ameloblastic carcinoma with amyloid tumor in a miniature dachshund
By Izzati, U Z et al.·Published in Journal of comparative pathology·2019·Department of Veterinary Pathology, Japan·View original on PubMed →
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Original publication title: Immunohistochemical Profile of Ameloblastic Carcinoma Arising from an Amyloid-Producing Odontogenic Tumour in a Miniature Dachshund.
- Species:
- dog
Plain-English summary
A 13-year-old female miniature dachshund was brought to the vet with a painful mass under her tongue that was affecting her teeth. A biopsy showed that the mass was an ameloblastic carcinoma, a type of cancer that can develop from certain benign tumors. The vet performed surgery to remove the affected part of her jaw, and while the cancerous cells were confirmed, the tumor also contained some benign tissue. The dog was diagnosed with ameloblastic carcinoma that arose from a benign amyloid-producing odontogenic tumor.
People also search for: dog mouth tumor treatment · dachshund oral cancer symptoms · ameloblastic carcinoma in dogs
Abstract
A 13-year-old female miniature dachshund was presented with a centrally-located sublingual mass in the rostral mandibular region. The focally ulcerated growth completely covered the left (305) and right (405) premolar teeth and partially covered the right canine teeth (404). A punch biopsy sample revealed neoplastic proliferation of odontogenic epithelium arranged in irregular cords with frequent comedo-like necrosis. Following the initial diagnosis of ameloblastic carcinoma, a bilateral rostral hemimandibulectomy was performed. Although the detailed examination of the resected mass was consistent with the initial diagnosis, it also contained birefringent congophilic, amelogenin-labelled amyloid deposits similar to an amyloid-producing odontogenic tumour (APOT) in 30-40% of the mass, in continuity with the ameloblastic carcinoma. All neoplastic cells had diffuse moderate expression of cytokeratin (CK) AE1/AE3 and CK5, diffuse mild expression of CK14 and multifocal moderate expression of CK19. Because the APOT-like growth in the mass was histologically benign, the tumour was diagnosed as an ameloblastic carcinoma arising from an APOT.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30691607/